Originally Posted by
g.man10mm
I'm assuming that this is intended as a grizzly-defense/dangerous game round in the neighborhood of the Buffalo Bore and Garrett 45-70 rounds? If so, I recently did a similar work up with IMR 4198 for my brother in Alaska and I'd be happy to share what I learned from that, quite a bit of research, test, and evaluation went it to it.
If you intend it for less extreme situations, I'd highly recommend going quite a bit lighter (as other responses have as well), maybe in the 1200-1400fps range. (At 42 gr of 4198, 385 gr NOE bullet (around 1800 fps or so) in Buffalo Bore small primer brass, while accuracy was excellent, and no signs of excess pressure were evident, my note says "Shoulder-crushing recoil."- and it was) In my Guide Gun, even with proper technique and shooting position and as a largish, fit shooter with a lifetime of powerful cartridges in light guns, I found it quite unpleasant to shoot- observers politely declined the opportunity. Certainly doable, but won't tolerate it without a darn good reason.